Like many stories, ours began with a problem. While working in pharmaceutical manufacturing, Eric Graban found himself driven to find better ways of measuring the integrity of protein structures. With patient safety at stake, he grew increasingly frustrated that existing technologies for day-to-day measurements of protein structure were limited, low resolution techniques such as FTIR or SEC. More discouraging was knowing that high resolution techniques available in the most advanced protein analytical laboratories could be a valuable tool for supporting day-to-day decisions; but the time, expense, and expertise required to obtain (or even access) the equipment or facilities needed for these techniques effectively put them out of reach.
Eric sought a way to bring a high-resolution capability to locations that did not have the time, budget, or resources to access the type of data provided by latest cutting edge technologies. He soon found the solution in research performed by Dr. Richard Vachet at UMass, Amherst. Dr. Vachet’s mass spectrometry-based covalent labeling technology provided the ideal combination of high resolution analysis of protein structure, while not requiring the highly specialized equipment or expertise needed for comparable technologies. A joint research program demonstrated the feasibility of the technology at detecting even subtle changes in protein structure and identifying the specific location of the changes in the structure.
QuarryBio has since expanded to include work with Dr. Robert Vaughan in the Biotechnology Program at Indiana University, as well as our own in-house mass spectrometrists, whose depth of expertise in mass spec data analysis has allowed us to develop a proprietary data analysis software program uniquely suited to this application. That work has demonstrated the effectiveness of epitope mapping and protein structure analysis across multiple applications for our biotech clients.