Mass Spectrometry (MS) and Surface Plasmon Resonance (SPR) Services

QuarryBio now offers Mass Spectrometry (MS) and Surface Plasmon Resonance (SPR) services for characterization of proteins (including antibodies), peptides, and small molecules. A listing of our instrumentation and capabilities are shown below.

Analytical Instrumentation

  • HPLC/UV
    • Dionex Ultimate 3000/4-Channel Variable Wavelength Detector
  • HPLC/MS/MS
    • Orbitrap Elite High Resolution Mass Spectrometer
  • Biacore X100+ SPR
  • NanoDrop 2000c

Services Provided

MS/LCMS:

  • Covalent labeling studies to identify:
    • Binding sites for protein interactions
    • Changes in protein structure
  • Biophysical characterization
    • Protein identification
    • Post translational modifications
    • Peptide mapping
  • Proteomics
  • Targeted metabolomics
  • Small molecule mass confirmation
  • We are developing methods to perform protein analysis studies in a living cell environment
    • High resolution epitope mapping/ligand-substrate binding studies using membrane proteins in living cells
    • BioID using biotinylation to map intracellular protein interactions via proximity labeling from a target protein

Protein/Cell Culture:

  • Protein expression using mammalian cells or e. coli
  • Stable cell line development
  • Molecular cloning services

Other Capabilities:

  • Sample analysis via HPLC/UV
  • Surface Plasmon Resonance for:
    • Kinetic/affinity analysis of ligand/analyte interaction
    • Binding analysis, including binding specificity and comparative ranking
  • We are available to discuss other possible projects not covered in this list

Pricing: quotes will be generated for each proposed project